Publications
January 04, 2023
Oleg Dmytrenko, Gina C. Neumann, Thomson Hallmark, Dylan J Keiser, Valerie M. Crowley, Elena Vialetto, Ionnis Mougiakos, Katharina G Wandera, Hannah Domgaard, Johannes Weber, Josie Metcalf, Benjamin N Gray, Matthew B Begemann*, Ryan N Jackson*, Chase L Besiel*, (2023) Cas12a2 elicits abortive infection through RNA-triggered destruction of dsDNA, Nature 613, 588-594, https://www.nature.com/articles/s41586-022-05559-3
June 13, 2022
Oleg Dmytrenko, Gina C. Neumann, Thomson Hallmark, Dylan J Keiser, Valerie Crowley, Elena Vialetto, Ionnis Mougiakos, Katharina G Wandera, Hannah Domgaard, Johannes Weber, Josie Metcalf, Matthew B Begemann, Benjamin N Gray*, Ryan N Jackson*, Chase L Besiel*, (2022) Cas12a2 elicits abortive infection via RNA-triggered destruction of double-stranded DNA, BioRxiv doi: https://doi.org/10.1101/2022.06.13.495973 *co-corresponding author
June 13, 2022
Jack PK Bravo, Thomson Hallmark, Bronson Naegle, Chase L Beisel, Ryan N Jackson, David W Taylor, (2022) Large-scale structural rearrangements unleash indiscriminate nuclease activity of CRISPR Cas12a2 co-first author *co-corresponding author
May 21, 2021
Hannah Taylor, Eric Laderman, Matt Armbrust, Thomson Hallmark, Dylan Keiser, Joseph Bondy-Dennomy, Ryan N Jackson* (2021) Positioning Diverse Type IV Structures and Functions Within Class 1 CRISPR Systems. Frontiers in Microbiology. 12:671522. doi:10.3389/fmicb.2021.671522 *corresponding author
March 19, 2021
Yi Zhou, Jack PK Bravo, Hannah N Taylor, Jurre Steens, Ryan N Jackson*, Raymond HJ Staals*, David W Taylor* (2021) Structure of a type IV CRISPR-Cas ribonucleoprotein complex Science 24 (3) https:doi.org/10.1016/j.isci.2021.102201 *co-corresponding author
November 27, 2019
Crowley, V.M, Catching, A., Taylor, H.N, Borges, A.L, Metcalf, J., Bondy-Denomy, J., Jackson, R.* (2019). A Type IV-A CRISPR-Cas System in Pseudomonas aeruginosa Mediates RNA-Guided Plasmid Interference In Vivo. The CRISPR Journal *corresponding author
June 28, 2019
Taylor, H.N, Warner, E.E, Armbrust, M.J, Crowley, V.M, Olsen, K.J, Jackson, R.* (2019). Structural basis of Type IV CRISPR RNA biogenesis by a Cas6 endoribonuclease. RNA biology, 16:10, 1438-1447. *corresponding author
November 02, 2018
Kunne, T., Zhu, Y., da Silva, F., Konstantinides, N., McKenzie, R.E, Jackson, R., Brouns, S.J (2018). Role of nucleotide identity in effective CRISPR target escape mutations. Nucleic acids research, 46:19, 10395-10404.
February 16, 2018
van Erp PBG, Patterson, A., Kant, R., Berry, L., Golden, S.M, Forsman, B.L, Carter, J., Jackson, R., Bothner, B., Wiedenheft, B. (2018). Conformational Dynamics of DNA Binding and Cas3 Recruitment by the CRISPR RNA-Guided Cascade Complex. ACS chemical biology, 13:2, 481-490. doi: doi.org/10.1021/acschembio.7b00649
June 21, 2017
Jackson, R.*, van Erp, P.B*, Sternberg, S.H, Wiedenheft, B.* (2017). Conformational Regulation of CRISPR-associated Nucleases. Current Opinion in Microbiology, 37, 110-119. doi: https://doi.org/10.1016/j.mib.2017.05.010 *co-corresponding authors
March 23, 2017
Chowdhury, S., Carter, J., Rollins, M.F, Jackson, R.N, Hoffman, C., Nosaka, L., Bondy-Denomy, J., Davidson, A.R, Fischer, E.R, Lander, G.C, Wiedenheft, B. (2017). Structure reveals mechanisms of viral suppressors that intercept a CRISPR RNA-guided surveillance complex. Cell, 169:1, 47-57.
September 06, 2016
Luo, M.L, Jackson, R., Denny, S.R, Tokmina-Lukaszewska, M., Maksimchuk, K.R, Lin, W., Bothner, B., Wiedenheft, B., Beisel, C.L (2016). The CRISPR RNA-guided surveillance complex in Escherichia coli accommodates extended RNA spacers. Nucleic Acids Research, 44:15, 7385-94.
September 30, 2015
van Erp, P.B, Jackson, R.N, Carter, J., Golden, S.M, Bailey, S., Wiedenheft, B. (2015). Mechanism of CRISPR-RNA guided recognition of DNA targets in Escherichia coli. Nucleic Acids Research, 43:17, 8381-91.
July 30, 2015
Jackson, R., McCoy, A.J, Terwilliger, T.C, Read, R.J, Wiedenheft, B. (2015). X-ray structure determination using low-resolution electron microscopy maps for molecular replacement. Nature Protocols, 10:9, 1275-84.
June 04, 2015
Jackson, R., Wiedenheft, B. (2015). A Conserved Structural Chassis for Mounting Versatile CRISPR RNA-Guided Immune Responses. Molecular Cell, 58:5, 722-8.
December 16, 2014
Taylor, L.L, Jackson, R., Rexhepaj, M., King, A.K, Lott, L.K, van Hoof, A., Johnson, S.J (2014). The Mtr4 ratchet helix and arch domain both function to promote RNA unwinding. Nucleic Acids Research, 42:22, 13861-72.
September 19, 2014
Jackson, R., Golden, S.M, van Erp, P.B, Carter, J., Westra, E.R, Brouns, S.J, van der Oost, J., Terwilliger, T.C, Read, R.J, Wiedenheft, B. (2014). Structural biology. Crystal structure of the CRISPR RNA-guided surveillance complex from Escherichia coli. Science, 345:6203, 1473-9.
June 09, 2014
van der Oost, J., Westra, E.R, Jackson, R., Wiedenheft, B. (2014). Unravelling the structural and mechanistic basis of CRISPR-Cas systems. Nature Reviews. Microbiology, 12:7, 479-92.
January 28, 2014
Jackson, R.N, Lavin, M., Carter, J., Wiedenheft, B. (2014). Fitting CRISPR-associated Cas3 into the Helicase Family Tree. Current Opinion in Structural Biology, 24, 106-14.
September 05, 2013
Westra, E.R, Semenova, E., Datsenko, K.A, Jackson, R., Wiedenheft, B., Severinov, K., Brouns, S.J (2013). Type I-E CRISPR-cas systems discriminate target from non-target DNA through base pairing-independent PAM recognition. PLoS Genetics, 9:9, e1003742.
September 20, 2012
Johnson, S.J, Jackson, R. (2013). Ski2-like RNA helicase structures: common themes and complex assemblies. RNA Biology, 10:1, 33-43.
May 28, 2010
Jackson, R., Klauer, A.A, Hintze, B.J, Robinson, H., van Hoof, A., Johnson, S.J (2010). The crystal structure of Mtr4 reveals a novel arch domain required for rRNA processing. The EMBO Journal, 29:13, 2205-16.
